This followed with major roles in What's Eating Gilbert Grape, Natural Born Killers, Strange Days, The Evening Star, Kalifornia, From Dusk till Dawn, The Other Sister and Conviction.Her work in television has resulted in two Emmy nominations.
Lewis launched a career as a singer and musician, leading the American rock band Juliette and the Licks until 2009 when she launched a solo career.
She also played Audrey Griswold in National Lampoon's Christmas Vacation.
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She gained fame for her role in Martin Scorsese's 1991 remake of the thriller Cape Fear for which she was nominated for both an Academy Award and Golden Globe for Best Supporting Actress.
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In 2015, she had a small role in the television series Wayward Pines, a psychological thriller by M. Lewis features on the track "Bad Brother" by the band The Infidels, from The Crow: Salvation Soundtrack album, which was released on April 2000.
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Lewis appeared in Rockstar Games' Grand Theft Auto IV, providing the voice of "Juliette", the host of fictional radio station "Radio Broker" (on which appears the Juliette and the Licks song 'Inside the Cage)'.
She reprised her role as Audrey Griswold in 2012 in a series of Old Navy holiday commercials featuring the Griswold family.
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